Research

Research activities and significant contributions to the field of Radiopharmacy over the last decade are listed below.

Publications

  1. BELLEN JC, CHATTERTON BE, PENGLIS S, TSOPELAS C. “Gallium-67 complexes as radioactive markers to assess gastric and colonic transit.” J Nucl Med, 36:3, 513-517, 1995.
  2. CHUNG ML, CAI ZJF, BARTHOLOMEUSZ FDL and PENGLIS S. “Corticosteroid therapy does not reduce the accuracy of Tc-99m colloid leukocyte scans in inflammatory bowel disease (IBD)”. Australian and New Zealand Journal of Medicine, 26, 752, 1996.
  3. TSOPELAS C, PENGLIS S. An alternative sedimenting agent for the in vitro labelling of 99mTc-HMPAO white cells. Aust NZ Soc Nucl Med J, 1997; 4: 12.
  4. TSOPELAS C. “Radiolabelling of 4-iodo-N[(2 morpholionethyl)benzamide with Na123I and Na125I”. Nuc Med Biol, 1999; 26: 591-595.
  5. BARTHOLOMEUSZ FDL, CHATTERTON BE, BELLEN JC, GAFFNEY R, HUNTER A. Segmental colonic transit after oral 67Ga-Citrate in healthy subjects and those with chronic idiopathic constipation. J Nucl Med, 1999; 277-282.
  6. PANDOS G, PENGLIS S, TSOPELAS C. Validation of a Column Method for the Quality Control Determination of Technetium-99m Exametazime. J Nucl Med Technol. 1999; 27: 306-8.
  7. PENGLIS S, TSOPELAS C. “Feasibility of fractionating Myoview cold kits and two new Quality Control Methods”. Nuc Med Comm, 2000; 21(5): 469-72.
  8. TSOPELAS C. “Technetium-99m labelling of a molecule bearing easily reducible groups”. Nucl Med Biol, 2000; 27(8): 797-802.
  9. TSOPELAS C, PENGLIS S. “Visualisation of lymphatic flow in a rabbit model using 99mTc-labelled dyes”. Hellenic J Nucl Med, 2000; 3: 96-101.
  10. TSOPELAS C, BRUNDELL S, CHATTERTON BE. “A simple and inexpensive preparation of [51Cr]-MAA particles”. Nucl Med Biol, 2001; 28(3): 21-26.
  11. TSOPELAS C. “Particle size analyses of 99Tc-labelled and unlabelled rhenium sulfide and antimony trisulphide colloids for their application in lymphoscintigraphic studies”. J Nucl Med, 2001; 42: 467-475.
  12. PENGLIS S, TSOPELAS C and BARTHOLOMEUSZ FDL. “99mTc-Phosphomycin as a potential infection imaging agent”. Hellenic J Nuc Med, 2001; 4(3): 161-164.
  13. SUTTON R, TSOPELAS C, CHATTERTON BE, COVENTRY B, KOLLIAS J. “Sentinel node biopsy and lymphoscintigraphy with a technetium 99m labelled blue dye in a rabbit model”. Surgery, 2002; 131(1): 44-49.
  14. BRUNDELL SM, TSOPELAS C, CHATTERTON B, TOULOUMTZOGLOU J, HEWETT PJ. “Experimental study of peritoneal blood flow and insufflation pressure during laparoscopy”. Br J Surg, 2002; 89: 617-622.
  15. ANDERSON DL, BARTHOLOMEUSZ FDL, KIRKWOOD ID, CHATTERTON BE, SUMMERSIDES G, PENGLIS S, KUCHEL T, SANSOM L. “Gastric emptying in the pig: the effect of concentration of inhaled isoflurane”. J Nuc Med, 2002; 43: 968-971.
  16. TSOPELAS C, PENGLIS S, ROSELT P, BELLEN JC. “Biodistribution of a potential brain imaging agent, 4-iodo [123I]-N[(2 morpholionethyl)benzamide”. Hellenic J Nuc Med, 2002; 5(1): 30-35.
  17. TSOPELAS C, MUNNS S, DANIELS CB, LAI C, COOTER RD, CHATTERTON B. “Biodistribution and lymphatic speed of 99mTc-antimony trisulphide colloid in the lizard Pogona vitticeps”. Hellenic J Nuc Med, 2002; 5(1): 42-45.
  18. TSOPELAS C and SUTTON R. “Why certain dyes are useful for localising the sentinel lymph node”. J Nuc Med, 2002; 43(10): 1377-1382.
  19. TSOPELAS C, SUTTON R, CHATTERTON B, KOLLIAS J, COVENTRY B. “Behaviour of 99mTc-Evans blue in the lymphatic system”. Aust NZ Soc Nuc Med J, 2002; 33(3): 103-107.
  20. TSOPELAS C, PENGLIS S, BARTHOLOMEUSZ FDL. “Comparison of 99mTc-alafosfalin and 67GIa-citrate in a mouse model of bacterial infection”. Nuclear Medicine Review 2002; 5(2): 93-97.
  21. TSOPELAS C, PENGLIS S, RUSZKIEWCZ A and BARTHOLOMEUSZ FDL. “99mTc-Alafosfalin: A potential new antibiotic peptide for imaging bacterial infection”. Nucl Med Biol, 2003; 30(2): 169-175.
  22. DANIELS CB, LEWIS BC, TSOPELAS C, MUNNS SL, ORGEIG S, BALDWIN ME, STACKER SA, ACHEN MG, CHATTERTON BE, COOTER RD. “Regenerating lizard tails: A new model for investigating lymphangiogenis”. FASEB 2003; 17(3): 479-481.
  23. BRUNDELL SM, TSOPELAS C, CHATTERTON B, TOULOUMTZOGLOU J, BLEFARI C and HEWETT PJ. “The effect of trocar composition on tumour cell adherence: an in vivo model”. Dis Colon Rectum, 2003; 46(5): 637-42.
  24. TSOPELAS C, COLLINS PJ, BLEFARI C. “A simple and effective technique to reduce staff exposure during the preparation of radiopharmaceuticals”. J Nucl Med Technol, 2003; 31 (1): 37-40.
  25. TSOPELAS C, PENGLIS S, RUSZKIEWCZ A, BARTHOLOMEUSZ FDL. “Inflammation imaging with 99mTc-alafosfalin in a rat model of colitis”. Hellenic J Nucl Med 2003; 6(1): 33-37.
  26. TSOPELAS C, SMITH E, DREW PA, BARTHOLOMEUSZ FDL. “Preparation and biological evaluation of 99mTc-stannous fluoride colloid-labelled leucocytes in rats”. J Labelled Comp Radiopharm, 2003; 46: 751-763.
  27. TSOPELAS C. “Understanding the radiolabelling mechanism of 99mTc-antimony sulphide colloid”. Applied Radiation and Isotopes 2003; 59: 321-328.
  28. GOULD AR, SHARP PJ, SMITH DR, STEGINK AJ, CHASE CJ, KOVACS JC, PENGLIS S, CHATTERTON BE, BUNN CL. “Increased permeability of psoriatic skin to the protein, plasm activator inhibitor 2”. Arch Dermatol Res, 2003; 295(6): 249-254.
  29. TSOPELAS C, SUTTON R. “Formation of sulphonamide bonds through reaction of dyes with serum proteins”. J Nuc Med 2003; (Letter to the Editor) 44(9): 1540-1541.
  30. CHATTERTON BE, PENGLIS S, KOVACS JC, PRESNELL B, HUNT B. “Comparison of retention and distribution of two 99mTc-DTPA labelled vaginal dosage forms”. International J Pharmaceutics, 2004; 271/1-2 : 137-143.
  31. TSOPELAS C. “A study of the distribution of dextran as a sedimenting agent during the 99mTc-HMPAO leukocytes labeling procedure”. Hellenic J Nucl Med. 2004;46:751-763.
  32. ROFFEY DM, LUSCOMBE ND, BYRNE NM, HILLS AP, BELLON M, TSOPELAS C, KIRKWOOD ID, WITTERT GA. “Use of [14C]-sodium bicarbonate/urea to measure physical activity induced increases in total energy expenditure in free-living healthy males”. Asia Pac J Clin Nutr. 2005;14(1):83-90.
  33. TSOPELAS C, SMYTH D. “Characterization and Quality Control Analysis of 99mTc-Bicisate”. J Nucl Med Technol. 2005;33:89-93.
  34. SOJAN SM, SMYTH DR, TSOPELAS C, MUDGE D, COLLINS PJ, CHATTERTON BE. “Pharmacokinetics and normal scintigraphic appearance of 99mTc aprotinin”. Nucl Med Commun. 2005;26:535-9.
  35. TSOPELAS C. “Clinical radiotracers for mapping the lymphatic system”. Aust NZ Soc Nucl Med J. 2005;36(2):75-77.
  36. TSOPELAS C, COOPER R. “Radiolabelling and biodistribution of 111In-antimony trisulphide colloid”. Hellenic J Nucl Med. 2005;8:109-112.
  37. SMYTH D, TSOPELAS C. “An improved 99mTc-aprotinin kit formulation: Quality control analysis of radiotracer stability and cold kit shelf life”. Nucl Med Biol. 2005;32(8):885-889.
  38. TSOPELAS C. “The radiopharmaceutical chemistry of 99mTc-tin fluoride colloid-labeled-leukocytes”. Q J Nucl Med Mol Imaging. 2005;49(4):319-242.
  39. TSOPELAS C, BEVINGTON E, KOLLIAS J, SHIBLI S, FARSHID G, COVENTRY C, CHATTERTON B. “99mTc-Evans Blue dye for mapping contiguous lymph node sequences and discriminating the sentinel lymph node in an ovine model”. Ann. Surg. Oncol. 2006;13(5):692-700.
  40. TSOPELAS C, BARTHOLOMEUSZ FDL. “A potential lung perfusion imaging agent ofsynthetic origin”. J Labelled Comp Radiopharm, 2006;49(4):367-375.
  41. TSOPELAS C. “Physico-chemical characterisation of 99mTc-tin fluoride colloid agent used for labelling white cells”. J Labelled Comp Radiopharm. 2006;49(6):505-516.
  42. SMYTH DR. " Rapid determination of the radiochemical purity of 99mTc-antimony trisulfide colloid prepared by standard and alternative heating methods" J Nucl Med Technol. 2006 Sep;34(3):174-8.
  43. TSOPELAS C, PENGLIS S, RUSZKIEWCZ A, BARTHOLOMEUSZ FDL. “Scintigraphic imaging of experimental colitis with technetium-99m-infliximab in the rat”. Hellenic J. Nucl. Med. 2006; 9(2): 85-89.
  44. TSOPELAS C, CHEW G, CHEW J, COATES T, RUSS GR. “The distrbution of allogeneic 111In-dendritic cells in sheep”. Aust NZ Soc Nucl Med J. 2006; 37(2): 7-11.
  45. GREEN M, FARSHID G, KOLLIAS J, CHATTERTON BE, TSOPELAS C. “The tissue distribution of Evans Blue Dye in a sheep model of sentinel node biopsy”. Nuc Med Commun. 2006: 27(9):695-700.
  46. LUSCOMBE ND, TSOPELAS C, BELLON M, CLIFTON PM, KIRKWOOD I, WITTERT GA. “Use of [14C]-sodium bicarbonate/urea to measure total energy expenditure in overweight men and women before and after low calorie diet induced weight loss”. Asia Pac J Clin Nutr. 2006;15(3):307-16.
  47. TSOPELAS C, PENGLIS S, MILLER D, RISCHMEULLER M, BARTHOLOMEUSZ FDL. “Evaluation of 99mTc-immunoglobulins for imaging infection in the rat”. J Lab Cmpds Radiopharm. 2006;49(10):915-928.
  48. BLACKER HA, TSOPELAS C, ORGEIG S, DANIELS CB, CHATTERTON BE. “How regenerating lymphatics function: Lessons from lizard tails”. Anat Rec (Hoboken). 2007; 290(1):108-114.
  49. TSOPELAS C. “Recent advances in nuclear medicine: Radiopharmaceutical chemistry of agents for lymphoscintigraphy and the sentinel node biopsy”. In: Cancer Metastasis Research. Akira Watanabe (Ed.). 2008; Nova Science Publishers Inc: New York.
  50. LITTLE TJ, RUSSO A, MEYER JH, HOROWITZ M, SMYTH DR, BELLON M, WISHART JM, JONES KL, FEINLE-BISSET C. " Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides."
    Gastroenterology. 2007 Oct;133(4):1124-31.

Patents

Tsopelas C, Penglis S. [Inventors] Radioiodinated brain imaging agents - Preparation of [123I]-4-iodo-N-(2-morpholinoethyl)benzamide and analogues for neurological disorders of the human brain. [Provisional Patent; Application # A006881], 1993.

Awards


Honours

  1. BELLEN JC, PENGLIS S, TSOPELAS C. An alternative radiopharmaceutical to 111In-DTPA for colonic transit studies. [ANSTO Award Winner] Aust NZ J Med. 1992; 22(4): 414.
  2. TSOPELAS C, PENGLIS S, BELLEN J, SCHULTZ C, CHATTERTON B. Synthesis and biodistribution of [123I]-4-iodo-N-(2-morpholinoethyl)benzamide - one molecule in a class of potential brain imaging agents. Conference, Canberra. [ANSTO Award Finalist] Aust NZ J Med. 1994; 24: 513.
  3. PENGLIS S, TSOPELAS C. An evaluation of 99Tcm-phosphomycin for the localisation of bacterial infection. Conference, Perth. [ANSTO Award Finalist] Nucl Med Commun. 1999; 20: 370.
  4. LUSCOMBE N, KIRKWOOD I, BELLON M, TSOPELAS C, WITTERT G. Measurement of energy expenditure in overweight men and women using [14C]-bicarbonate-urea before and after weight loss. Conference, Queensland, 2001. [Best Student Presentation Winner]
  5. TSOPELAS C, MUNNS S, LAI C, DANIELS CB, COOTER RD, CHATTERTON BE. Biodistribution of 99mTc-antimony trisulphide colloid in a species of squamate versus rats. Conference, Hobart, 2001. [Poster] [ANZSNM Prize Finalist]
  6. M GREEN, J KOLLIAS, B CHATTERTON, C TSOPELAS. Identification of the sentinel lymph node in patients with invasive breast cancer using 99mTc-Evans Blue dye. Conference, Melbourne, 2005. [Poster] [Toshiba Prize Finalist]
  7. TSOPELAS C, FDL BARTHOLOMEUSZ. A potential lung perfusion imaging agent of synthetic origin. Australian New Zealand Society of Nuclear Medicine Annual Conference, Melbourne. [Oral Presentation] [ANSTO Award Finalist]
  8. Adam B, Tsopelas C, Liebregts T, Bartholomeusz FDL, Ruszkiewicz A, Holtmann G. Genetic Differences Determine Inflammatory Response and Development of Visceral Hyperalgesia in a Rat Model. Digestive Diseases Week Conference, Los Angeles, 2006. [Poster] [Poster Award Winner]


 

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